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Its been studied and indicated for people with either type 2 diabetes or the medical problem of overweight and/or obesity. Ozempic was approved by the FDA in 2017 and patients taking the drug for up to two years were included in safety trials
Importantly, while folic acid successfully decreases these toxicities, it does not alter or compromise the clinical efficacy of low-dose methotrexate in controlling joint inflammation and disease activity parameters (Friedman & Cronstein, 2019)
Semaglutide, a weekly injection, has demonstrated superior efficacy in adult head-to-head trials and is becoming a preferred option when accessible
The GIP component enhances the metabolic benefits, improving insulin sensitivity and possibly reducing the GI side effects compared to pure GLP-1 agonism
Oct 2020;70(10):1762-1766