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2.6 Utilities Baseline HRQoL was estimated using a regression-based function of BMI, derived from baseline data in the STEP 8 trial, an approach also adopted in previous cost-effectiveness studies ( Baseline Utility = 0.942975 0.0005414 * Age 0.0742818 * HeartCirc 0.0097531 * Hypertension + 0.0039044 * Smoke_Current 0.0081972 * Smoke_Previous + 0.0065954 * BMI 0.0002476 * BMI 2 + 0.00000175 * BMI 3 0.0031133 * Prediabetes (Supplementary Table 3)

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