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7 In fact, xCT is considered to be the main transporter of cystine in cancer (Table 1) 25,26,27 and its expression is controlled by nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of the cellular redox state, 28 highlighting the importance of xCT in an oxidative stress-resistant cancer cell phenotype

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Also, consistent with earlier experiments in parental cell lines, BPM31510 treatment significantly increased G3P-driven ROS production (Fig

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Pharmacokinetic studies in rats and beagle dogs reveal that BPC-157 exhibits linear pharmacokinetic characteristics across all tested doses

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