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Additionally, further investigations are underway to explore potential additional uses of tirzepatide in the clinical management of other cardiometabolic conditions associated with obesity, including heart failure and non-alcoholic (or metabolic-dysfunction associated) steatohepatitis (NASH/MASH)

These analogs emulate endogenous GLP-1 by activating GLP-1R, stimulating release of insulin

MHRA/EMC SmPCs for semaglutide and liraglutide

It has also been linked to behavior like anger and aggression in children

Discussion Mounting evidence implicates that obesity represents a state of long-term, low-grade inflammation, and ATMs are a significant contributor to systematic inflammation and dysfunctional insulin action in obese individuals [51]

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