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2-adrenoceptor agonists Clonidine gel: A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial showed that topical clonidine gel significantly reduced the level of pain in subjects with DN in whom there are functional (and possibly sensitized) nociceptors in the affected skin

Iyer SS, Accardi CJ, Ziegler TR et al (2009) Cysteine redox potential determines pro-inflammatory IL-1 levels

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Nanoparticles labeled with a mUNO peptide (CSPGAK), which is a CD206-binding peptide, promote selective drug delivery to M2-type TAMs and induce M2 to M1 reprogramming of the macrophage phenotype 33

[5] Twarog, C., Fattah, S., Heade,J., Maher, S., Fattal, E., & Brayden, D

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