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Providers often recommend backup contraception (such as condoms) during the first weeks of GLP-1 therapy initiation, when dosing adjustments are most frequent and gastric changes are most pronounced

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Constipation occurs in 20-40% of GLP-1 users due to slower gastric emptying and reduced intestinal motility, making it one of the most common gastrointestinal side effects reported in clinical trials and real-world use

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