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FIGURE 2 The gut microbes first metabolize choline and L-carnitine to volatile trimethylamine (TMA)

Unlike older antidiabetic drugs [31,32,33], these drugs lower blood pressure and do not cause weight gain [34]

Bibcode:2004JExpB.207..945D

Due to their remarkable ability to regulate metabolism, they have been widely adopted in the management of type 2 diabetes mellitus (T2DM) and obesity

Bikman points out that while type 1 diabetes is often understood as a condition of too little insulin, it can also be viewed as a condition of too much glucagon

Fatigue is another common issue, and it can be multifactorial: too few calories, iron deficiency, or simply the medication itself