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Tirzepatide activates two metabolic pathways simultaneously, making it potentially more effective but also newer with less long-term safety data

Physiol Rep 6:e13647 Hsu DC et al (2018) Central nervous system inflammation and infection during early, nonaccelerated simian-human immunodeficiency virus infection in rhesus macaques

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A First Look at the Numbers A 2026 study published in The Lancet Obstetrics, Gynaecology, and Women's Health took a direct look at this question, evaluating 120 postmenopausal women treated with tirzepatide, one of the most effective GLP-1 and GIP dual receptor agonists currently available [16]

Selecting an appropriate protein shake while taking tirzepatide requires consideration of both nutritional composition and gastrointestinal tolerability