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FIGURE 1 Stock solutions of 10 mg/mL EXE in Milli-Q water were prepared and acidified by the addition of HCl 1 N solution to reach a pH value below 2.8

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It also explains why simply lowering insulin resistance whether through weight loss, metformin, or, hypothetically, an incretin-based agent can improve both the metabolic and the reproductive dimensions of the syndrome: reducing hyperinsulinemia lowers the drive to ovarian androgen production and restores some SHBG, which is the biological basis for the interest in any potent insulin-sensitizing intervention