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Enterohepatic circulation of methotrexate in rats in vivo

However, because the disease known as Donnai-Barrow syndrome, which results from inherited mutations in the LRP2 gene, is not associated with vitamin B12 deficiency, the interactions between cubilin and LRP2 is not required for overall vitamin B12 homeostasis

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Blood glucose begins to rise, leading to prediabetes and eventually type 2 diabetes if untreated