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Folic acid and vitamin B12 act in synergy in the formation of DNA, and deficiencies can have serious consequences, both in performance horses with a high tissue turnover rate, and in pregnancy and growth of young foals.

Long-term safety monitoring includes periodic laboratory testing, but the medication appears safe for extended use in appropriate candidates

MMA testing before treatment is the most cost effective strategy compared with not testing MMA, with an incremental cost effectiveness ratio of 3946 per quality adjusted life year

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And despite being found in many foods, a B12 insufficiency or deficiency is relatively common

The first 1 mg crosses the steepest portion of the GIP curve