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For example, if your pen has an expiry date six months away but you removed it from the refrigerator today, you must discard it after 28 days at room temperature, even though the printed expiry date has not passed

This is the reason a higher A1c lowering effect is observed with GLP1 agonists, due to the FPG lowering effect

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Limitations include limited large-scale human clinical evidence, challenges in extrapolating in-vitro concentrations to in-vivo contexts, stability sensitivities (light, heat, alkaline pH), and variability in supplier purity