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This extensive binding dramatically reduces the uptake of native IGF-1, limiting its interaction with target tissue receptors

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With the higher dose of MT-1 there was significant skin darkening at some body site in all but 1 individual (patient 73)

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World Journal of Gastrointestinal Pathophysiology, 5 (4), 496-513

Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release