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PMID: 37599690
A study found that the NRF2-KEAP1 complex keeps shuttling constantly between the cytoplasm and the nucleus, and in the nucleus, the nuclear protein prothymosin competes for NRF2 binding to KEAP1 and enables the liberated NRF2 to activate NRF2 target genes [15]
Acknowledgments The authors would like to thank Editage (www.editage.cn) for English language editing
Each of these transformed not just daily life, but also the way people relate to the world around them
Clinical trials have shown their potential in the treatment of idiopathic pulmonary fibrosis (IPF, 2018), 32 Alzheimers disease (AD, 2023, 2024, 2025), 33,34,35 diabetic macular edema (DME, 2024), 35 etc