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Despite these recommendations, there is limited real-world data evaluating outcomes of GLP1-RAs specifically in patients with moderate to advanced CKD or ESRD

Bicarbonate act as acid when alkaline is added in the water as shown in the equation below: When acid is added in the water H 3 O + + HCO 3 - = H 2 O + CO 2 In the same way, bicarbonate act as base when acid is added in the water as shown in the equation below: When base is added in the water OH - + H 2 CO 3 = H 2 O + HCO 3 - /em In general, bicarbonate helps to stabilize the pH in the water and make it easier to control pH levels

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The extra time at each step does not reduce the eventual effectiveness of higher doses

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