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However, over an extended period of clinical medications, therapeutic failure is brought on by side effects like nephrotoxicity, neurotoxicity, and myelosuppression that impact the entire hematopoietic population and lead to the development of chemoresistance

Under proper medical supervision with regular monitoring, that's a navigable question

The family B1 GPCR: structural aspects and interaction with accessory proteins

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Marnett LJ: Oxyradicals and DNA damage