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Copper binding to the prion protein: structural implications of four identical cooperative binding sites

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Financial support and sponsorship This work was supported by Fondo de Investigacin Sanitaria-FEDER (PI25/00528) and CIBEROBN from the Spanish Instituto de Salud Carlos III, and the Department of Health of the Gobierno de Navarra (GN2025/52)

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This section explores the mechanisms by which AS-IV influences the key risk factors underlying arrhythmia, with the potential to exert therapeutic effects by controlling the impact of these risk factors (Figure 3)