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Sudden changes in the diet, especially increased or excessive grain or carbohydrate consumption, can decrease the PH in the rumen and disturb the thiamine production of the microorganisms there

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Currently, the key processes leading to neurodegeneration are thought to be oxidative stress, disruption of transitional metal homeostasis, and neuroinflammation [1, 2]

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Specific gut inflammation (190) and gut hyper-permeability (219) have been identified, and microbe and virus communities may also persist in ME/CFS blood and brain tissue (193)

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