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They were anesthetized with intramuscular injection of urethane (1.125 g/kg) and a catheter was introduced either into the portal vein or into the gastric vein
Tirzepatide is a novel medication that acts as a dual incretin mimetic, targeting both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors
Without knowing the target, the mechanism of action remains incompletely understood, and it is not possible to optimize the peptide-receptor interaction or predict off-target effects
In summary, nausea is a very common side effect of GLP-1 medications, but the good news is that it often fluctuates and tends to be worse within the first 24-48 hours after an injection before wearing off
HOW IT WORKS: 1
