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Fibromyalgia involves dysfunction in the nervous system's pain processinga condition called central sensitizationwhere the brain amplifies normal signals into chronic pain

These microbial and metabolic shifts correlated with improved muscle outcomes, including the downregulation of Atrogin-1 and MuRF-1

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For most patients, nausea is transient and self-limiting, typically improving within the first 4-8 weeks as the body adapts to the medication

These results point toward quantifiable temporal biomarkers that could be captured from simple daily self-reportsand potentially passive digital data