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Activation of innate immune cGAS-STING pathway contributes to Alzheimers pathogenesis in 5FAD mice

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Taper HS, Roberfroid MB

The most common mutation is a deletion that encompasses the first 10 exons of the gene along with portions of the CARKL gene upstream of CTNS

Additionally, a case report of a child with autistic disorder and cerebral folate deficiency showed the normalisation of low cerebral spinal fluid homocysteine following 2 weeks supplementation with 0.5 mg folinic acid/kg/day increasing to 1.0/kg/day for 3 months [54]

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