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These can take a variety of forms, including injections, oral pills, skin-attached patches, slow-release drugs, and more

IP administration creates rapid systemic spikes and clearance, triggering acute stress-response pathways

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10 Many efforts have been made in response to each process of the drug transportation, which have also been accompanied by reviews of latest progress in this field, but most of literature emphasize the BBB breakdown in specific brain disorders, 11,12,13,14 or give a general review of delivery strategies concentrating on the barrier physiology

Over a period of time, KD has been evaluated in 2 uncontrolled and 1 placebo-controlled clinical trial, while AMD has been evaluated in 1 clinically controlled open-labeled clinical trial for its efficacy against ASD [165]