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It was a pleasant surprise. We need to define this at a mechanistic level Singh said that although these findings are encouraging, more research is needed to better understand these associations

MLN3897 Plus Methotrexate in Patients With Rheumatoid Arthritis: Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of an Oral CCR1 Antagonist in a Phase IIa, Double-Blind, Placebo-Controlled, Randomized, Proof-of-Concept Study

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