Creatine is needed to provide the muscles with energy needed for short bursts of power and speed for activities such as sprinting and weightlifting
Abbreviations AChE: Acetylcholinesterase Bti : Bacillus thuringiensis israelensis CHC: Cuticular hydrocarbon CPR: NADPH-cytochrome P450 reductase CYP: Cytochrome P450 DDT: Dichlorodiphenyltrichlorethane F: Phenylalanine GABA: -Aminobutyric acid GST: Glutathione S -transferases H: Histidine kdr : Knockdown resistance L: Leucine LLINs: Long-lasting insecticide nets PBA1c: 3-Phenoxybenzyl alcohol PBA1d: 3-Phenoxybenzaldehyde PBAcid: 3-Phenoxybenzoic acid RDL : Resistance to dieldrin gene S: Serine Vssc: Voltage-sensitive sodium channel References World Health Organization
Free radicals also contribute to aging and diseases like cancer
In the senescent state, FOXO4 accumulates in PML (promyelocytic leukemia) nuclear bodies where it binds and sequesters p53, preventing p53 from activating the mitochondrial apoptotic pathway
Reported applications include NNMT enzyme inhibition assays measuring 1-methylnicotinamide formation or S-adenosylhomocysteine release, intracellular target-engagement assays in differentiated 3T3-L1 adipocytes where 5-Amino-1MQ reduced intracellular 1-methylnicotinamide with an EC near 2.3 M (Neelakantan et al., Biochem Pharmacol, 2018), membrane permeability and Caco-2 transport characterisation, methyltransferase selectivity panels covering COMT, DNMT1 and PRMT3, and rodent studies of NNMT inhibition in adipose tissue and liver following the antisense knockdown work of Kraus and colleagues (Nature, 2014)
Availability: In stock Research Applications Common Use Commonly studied for its role in tissue repair and recovery processes
