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Increased d-lactic acid theory Another theory regarding the reduced intestinal pH and increased gut permeability in ME/CFS patients is the increased production of D-lactic acid due to the overgrowth of Gram-positive bacteria such as Enterococci and Streptococci, which leads to systemic inflammation, immune activation, and oxidative stress [22, 44]

Actb was chosen as the reference gene for the normalization of the Akt1 , Nos1 , Nos2 , Nos3 , Mtor , Prkcg , Ptgs2 , Ptk2 ,and Vegfa gene expression data (Table 1)

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Excess accumulation of these metals has been implicated in oxidative stress and the aggregation of misfolded proteins in conditions like AD and PD [188]

Chest 144 (1), 266273

Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy