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This is done through acetylcholine, a neurotransmitter of which Acetyl-L-Carnitine is a precursor

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It is not widely appreciated, however, that in healthy individuals, gastric emptying of nutrients is regulated primarily by inhibitory neurohormonal feedback arising from their interaction with the small intestine, rather than intragastric mechanisms, and that both the length and region of small intestine exposed to nutrients modulate this feedback [12, 13]