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This safety profile contrasts sharply with full growth hormone, which carries risks of diabetes development, acromegaly (abnormal tissue growth), increased cancer risk, hypertension, and other systemic effects

However, its half-life is significantly shorter than that of other IGF-1 derivatives, lasting approximately 30 minutes [2, 3]

Loudness changes with stress or quiet

Alm disso, a farmacocintica desses compostos desafiadora: muitos possuem meia-vida curtssima (minutos) e baixa biodisponibilidade oral, exigindo injees frequentes ou tecnologias de modificao molecular para serem eficazes

doi: 10.1016/j.pharmthera.2021.107916 216 Prez de la LastraJ

Langan, 2017)