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Annu Rev Pharmacol Toxicol 44:32547, PMID: 14744249 Holmgren A, Lu J (2010) Thioredoxin and thioredoxin reductase: current research with special reference to human disease

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These trends of alterations in metabolite levels correspond to the proteomic data and indicated that estrogen depletion increased the proteomic phenotype, metabolic induction appeared to be strongly associated with glutathione depletion and oxidative stress in renal cells, and that HPL targeting rescued these trends toward an imbalance

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