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Our previous publications have shown the evidence that neuronal death process is implicated in seizure generation ( Lapatinib is a tyrosine kinase inhibitor which is approved for the treatment of breast cancer ( Oxidative stress is a critical factor contributing to neuronal death caused by severe and repetitive seizures ( Materials and Methods Chemicals and Reagents Erastin, lapatinib, ferrostatin-1 (Fer-1), liproxstatin-1 (Lip-1) and Ras-selective lethal small molecule 3 (RSL3) were obtained from Selleck Chemicals (Houston, TX, United States)

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