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[64] Consequently, considering the potential biphasic effects of GABA on growth hormone production, as well as other safety concerns, its usage is not recommended during pregnancy and lactation

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Some patients notice reduced fasting blood sugar and hunger within the first month, while others see HOMA-IR score improvements over a longer period

However, potential limitations included possible unblinding due to noticeable weight loss and the absence of assessments of joint structure or other pathological endpoints

*Final cost depends on BMI grading, treatment zones, and clinical complexity

doi:10.1016/j.gde.2005.09.007