They work by directly targeting the melanin, both over and under the skin surface, without causing any irritation
Clinical Update 5/29/2021 Don't Do This If You Need Iron If you're low in iron, be aware that many foods dramatically reduce absorption of iron from your diet
doi:10.1016/j.bbabio.2010.04.002, PMID: 20388492 Drechsel DA, Patel M (2010) Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system
It depends on formulation and protocol
Discuss your specific timing with your provider, as individual absorption patterns vary and personalized scheduling may improve tolerability
Subcutaneous fat is less affected, which is why tesamorelin does not produce the lean, deflated look associated with caloric restriction