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The key finding was that plasma concentrations in patients taking 8 mg of retatrutide (approximately 182 nanomolar) exceeded the effective concentrations observed in the laboratory, suggesting these cardiac effects are clinically relevant at therapeutic doses

But these are not lifestyle shortcuts

Journal of Traditional and Complementary Medicine 11 (5);390-399

Avoid strenuous exercise or heavy lifting for at least 24 hours if you experience weakness, dizziness, or fatigue

The US product information includes contraindications for personal or family history of medullary thyroid carcinoma and multiple endocrine neoplasia syndrome type 2, but these are not listed in the UK SmPC