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The combination produces greater weight loss than GLP-1 agonism alone

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Most protocols involve 1-2 small subcutaneous injections per week a technique most patients master in under 5 minutes

The peptide has been extensively studied in both preclinical models and human clinical trials, demonstrating consistent fat-reducing effects with a favorable safety profile

Physicians may opt to treat these patients and monitor for improvement of metabolic markers, particularly in populations at high risk of clinical vitamin B 12 deficiency, or observe these patients and periodically reassess their levels of vitamin B 12 , homocysteine, and/or methylmalonic acid