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Key information extracted from each included study encompassed study characteristics (first author, year of publication, study design, sample size, and participant demographics), intervention details (dosage, route of administration, treatment duration, and control conditions), and primary outcomes related to lipid profiles, specifically TC, TG, HDL, LDL, and VLDL

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Patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) should not take GLP-1 medications with the thyroid C-cell tumor boxed warning

Subcutaneous injections require sufficient length to penetrate skin and reach the fatty tissue layer beneath, where tirzepatide distributes optimally for systemic absorption