Over time, chronic energy deficiency can lead to fatigue, poor recovery, loss of muscle, hormonal disturbances, low energy availability and impaired performance a condition akin to RED-S (Relative Energy Deficiency in Sport)
However, they also say that a decent amount of muscle loss is par for the course for anyone losing weight rapidly, specifically highlighting those who have had bariatric surgery, and not necessarily specific to GLP-1s
Both GLP-1RA and SGLT-2 inhibitors were associated with the same lower risk (12%) as compared with placebo, and the same lower risk as compared with DPP-4 inhibitors (13%)
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Another technique involved measuring blood glucose uptake in diaphragms removed from rats
Liew WK, Kang PB