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Metformin Metformin, an antihyperglycemic agent used as first-line treatment for prediabetes and diabetes, might reduce the absorption of vitamin B12 and significantly reduce serum vitamin B12 concentrations

*Correspondence: Szymon Drygaa, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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To illustrate, the authors of that aforementioned 2012 review referred to a multicenter study of 80 children in which subjects received a daily subcutaneous injection equal to 30mcg/kg