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These cardiometabolic improvements matter because excess weight drives many of these risk factors

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The reduced enzymatic activity increases cellular concentrations of both substrates that NNMT would otherwise consume: S-adenosyl-L-methionine (the universal cellular methyl donor) and nicotinamide (the NAD + salvage precursor)

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The metabolomic analysis, which was performed to assess the mechanisms of the improvement of fatty liver by L-carnitine in more detail, demonstrated a 4.4-fold increase in the amount of L-carnitine found in the liver following L-carnitine administration