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Recent strategies to overcome these hurdles include the development of novel delivery systems such as gene-nanocarrier complexes, the use of human induced pluripotent stem cell-derived neural progenitor cells secreting GDNF (iNPC-GDNFs) for combined cell and gene therapy, and the exploration of small neurotrophic peptides like djGDNF47 generated via alternative splicing (Shamadykova et al., 2025

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