The first hit refers to early metabolic disturbances, including excessive triglyceride accumulation within hepatocytes, insulin resistance, hyperglycemia, and hyperlipidemialeading to steatosis
Hormonal Cascade When GH begins its downward slide, a domino effect is initiated throughout several hormones
As of 2024, there is no peer-reviewed clinical evidence demonstrating that commercially available GLP-1 patches deliver therapeutic outcomes comparable to FDA-approved GLP-1 medications
Boulland JL, Rafiki A, Levy LM, Storm-Mathisen J, Chaudhry FA: Highly differential expression of SN1, a bidirectional glutamine transporter, in astroglia and endothelium in the developing rat brain
doi:10.1146/annurev-psych-010418-102936 Stress eating is a hormonal loop, not a lack of discipline
Watanabe Y, Yamaguchi Y (2022) Drug allergy and autoimmune diseases