In summary, this limited and methodologically heterogeneous evidence base constrains the conclusions that can be drawn about how GLP-1 RAs affect brain responses to food-or drug-related cues, and substantial gaps remain in our understanding of their effects on central mechanisms of motivation and reward
It also slowed gastric emptying and reduced appetite, which immediately made it different from other diabetes hormones. The problem was timing: natural GLP-1 is broken down within minutes, making it impractical as a medication
It can cause some side effects including stomach upset, nausea, vomiting, dry mouth, headache, and restlessness
PLoS One 5 (8), e12461
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There are basically two mechanisms that cause nausea