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Unlike standard tablets, biologic drugs can degrade when exposed to temperatures that are too high or too low

Yu, Danxia et al

We further hypothesized that l-theanine, caffeine and their combination would improve impulse control by increasing reactivity of inferior frontal and dorsolateral prefrontal cortical regions of the brain that are thought to be the neural substrates of impulse control

Cardiovascular mortality, all-cause mortality, and diabetes incidence after lifestyle intervention for people with impaired glucose tolerance in the Da Qing Diabetes Prevention Study: a 23-year follow-up study

Finally, future perspectives of these therapies are briefly discussed

Importantly, hemodynamic effects - modest reductions in heart rate (+2-4 bpm) and blood pressure decreases - are generally well tolerated and beneficial in this population