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Dosing schedules vary depending on the specific medicine: Once-weekly injections : Dulaglutide and semaglutide (Ozempic) offer the convenience of weekly dosing, which many patients prefer Once-daily injections : Liraglutide and lixisenatide require daily administration Twice-daily injections : Exenatide (Byetta) is administered twice daily, before morning and evening meals Oral formulation : Semaglutide tablets (Rybelsus) are taken once daily on an empty stomach with up to 120 mL of water only , at least 30 minutes before the first food, drink, or other oral medicines of the day

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These can include headache, mild gastrointestinal discomfort such as nausea, difficulty sleeping, increased bruising tendency, and changes in mood

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