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Severe or persistent GI symptoms during GLP-1 use are reasons to contact your prescribing clinician promptly, particularly if you are experiencing signs of dehydration, severe constipation, or symptoms suggestive of intestinal obstruction

However, when weight loss occurs rapidly, as often seen with GLP-1 medications, the skins natural ability to retract can be outpaced

Liver and Metabolic Effects The liver plays a major role in metabolism

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However, in a recent abstract, the interim analysis of the REGENERATE trial showed lower patient-reported outcomes than the general population on a specific questionnaire (the chronic liver disease questionnaire-NASH), and the patient-reported outcomes improved with OCA treatment

In case of any side effects, immediately seek medical advice