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Statements Author contributions MD: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writingoriginal draft, Writingreview and editing

There were no significant differences among the three doses of lipoic acid, suggesting that 600 mg/day may be the maximum effective dose (55)

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However, unlike FASD in which ethanol induces a retinol deficiency through substrate competition, a retinoic acid deficiency in ASD is more likely to involve mutations associated with ALDH s, resulting in an accumulation of retinal and a much lower production of retinoic acid

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Wright, R