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Researchers should also consider the contraindications for semaglutide, including: History of thyroid cancer Multiple endocrine neoplasia syndrome type 2 (MEN 2) Pregnancy Lactation Known allergy to semaglutide Animal studies suggest that GLP-1-RAs, including semaglutide, could lead to reduced embryo size and developmental anomalies

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Results also demonstrated that the antibody was able to cross the blood-brain barrier in healthy volunteers

They published their study results in the medical journal JAMA Network Open

The resulting shortages led many patients to seek out compounded versions that cost a fraction of the brand-name price, setting the stage for todays legal battles