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As mechanistic insights into iron homeostasis, lipid peroxidation, and immunometabolic interactions continue to deepen, alongside progress in drug delivery, gene editing, and regenerative medicine, therapies targeting ferroptosis may represent a promising new paradigm in OA management, ultimately enhancing joint function and overall quality of life for affected individuals

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6.3 Selecting a GSH/GSSG Metabolomics Strategy The analytical strategy should follow the research question

GSH is covalently linked at the Cys32 residue) allowed us to identify another GSH binding site in the OsDHAR structure

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