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Abbreviations ACSF2: Acyl-CoA Synthetase Family Member 2 ACER1: Alkaline Sphingomyelinase 1 ACSL4: Long-chain acyl-CoA Synthetase 4 AMPK: Adenosine Monophosphate-activated Protein Kinase ALOX5: Arachidonate 5-Lipoxygenase ATP: Adenosine Triphosphate BCP: -caryophyllene CB2R: Cannabinoid Receptor 2 CD: Crohn's Disease CDAI: Crohns Disease Activity Index EBP: CCAAT/enhancer-binding protein CRP: C-Reactive Protein DSS: Dextran Sulfate Sodium DEGs: Differentially Expressed Genes DF: Dietary Fibers DHA: Docosahexaenoic Acid DPA: Docosapentaenoic Acid DLAT: Dihydrolipoamide S-acetyltransferase DMT1: Divalent Metal Transporter 1 EL: Methacrylic acid-ethyl acrylate copolymer FDX1: Ferredoxin 1 FPN1: Ferroportin 1 G-CSF: Granulocyte Colony-stimulating Factor GI: Gastrointestinal GZMA: Granzyme A GPX4: Glutathione peroxidase 4 GSH: Glutathione HON: Honokiol IBD: Inflammatory Bowel Disease IDA: Iron Deficiency Anemia IFN-: Interferon-gamma IGF2BP2: Insulin-like growth factor 2 mRNA-binding protein 2 IL-17: Interleukin-17 IRP1: Iron regulatory protein 1 LIAS: Lipoic Acid Synthetase LCN2: Lipocalin-2 LPO: Lipid Peroxidation MCP-1: Monocyte Chemoattractant Protein-1 m(6)A: N(6)-methyladenine MIP-1: Macrophage Inflammatory Protein-1 alpha NF-B: Nuclear Factor Kappa-B NLRP3: NOD-like Receptor 3 Nrf2: Nuclear factor erythroid 2-related factor 2 PAK6: Protein-activated Kinase 6 PHZ: Phlorizin PCA: Protocatechuic Acid PDE4: Phosphodiesterase 4 PVP: Polyvinylpyrrolidone QDTP-Zn: Qingzhuan dark tea polysaccharides-Zinc ROS: Reactive Oxygen Species RONS: Reactive Oxygen and Nitrogen Species SCFAs: Short-chain Fatty Acids SLC6A14: Solute Carrier family 6 member 14 SLC7A11: Solute Carrier family 7 member 11 SOCE: Store-operated Calcium Entry ssGSEA: Single-sample gene set enrichment analysis TCA: Tricarboxylic Acid TMCO1: Transmembrane region and Coiled helix region 1 TLR: Toll-like Receptor TRPV: Transient Receptor Potential Vanilloid TXNRD3: Thioredoxin Reductase 3 UC: Ulcerative Colitis VE: Vascular Endothelial WD: Wilsons Disease ZnBM: Baicalein-modified Zinc Phosphate HZn-TA: Hollow Zn-TA nanoparticles ZO-1: Zonula Occludens-1 References Murdoch CC, Skaar EP

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After gallbladder removal (cholecystectomy), your liver still produces bile, but it flows continuously into your intestines rather than being released in concentrated doses

The Phase 3 FLOW trial evaluated Ozempic in patients with T2DM and CKD

Constipation affects a significant percentage of patients

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