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So when it comes to estrogen hormone replacement therapy, that is helping restore the insulin sensitizing effects of estrogen, we also know that estrogen HRT can improve lipid profiles and it can blunt the visceral fat accumulation that we typically see in menopause

Journal of Circulation , 1995, 92:2825-30

Preclinical findings may suggest mechanisms worth studying, but limited human evidence cannot establish broad clinical effectiveness, optimal dosing, long-term safety, or superiority over standard care

Amin, M