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doi: 10.3389/fmed.2021.661076 47 HarrisonLEGiardinaCHightowerLEAndersonCPerdrizetGA

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These findings show that NAMPT overexpression promotes self-renewal properties, resulting in stemness-like maintenance, which ultimately leads to increased migration, dedifferentiation, and CSC-dependent resistance to therapy

Then, the rats were intranasally administered berberine chitosomes (0.5 mg/kg/day) for four weeks [48]

TB-500 sequesters G-actin monomers and promotes cytoskeletal remodeling, enabling repair cells to migrate to injury sites

Nevertheless, evidence for alternative topical formulations beyond these established agents remains limited and heterogeneous, with few randomized trials to date and largely observational data