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The thioesterase activity of ABHD11 against the glutaryl moiety was dependent on enzyme and substrate concentration (Extended Data Fig

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LC-MS/MS analyses of GS-CAM-TPP and GSS-CAM-TPP and their deuterated internal standards were performed using a Xevo TQ-S triple quadrupole mass spectrometer (Waters, UK)

In some embodiments, the formulations or compositions described herein are liquids and are administered via narrow gauge needles or cannulas (e.g., 22 gauge needle, 25 gauge needle, or cannula), minimizing damage to the tympanic membrane upon administration

The percentage of granulocytes ( Figure 3E ) showed an opposite trend, as it increased from 42 ap (51.92%) and peaked at 4 h pp (76.75%), followed by a decrease until 48 h pp to the initial level (52.78%) until the end of the trial